umbilical cord stem cells to treat lupus
Researchers at National Yang- Ming University, Taiwan, China, ensure that mesenchymal stem cells derived from umbilical cord blood may represent a new therapeutic alternative for the treatment of nephritis Lupus, a major complication of systemic lupus erythematosus.
This follows from the results of a study in mice whose results are published in its latest issue, the journal Cell in Transplantation. "
explains the study's lead author, Dr. Oscar K. Lee, these cells have been shown to possess immune-modulating capacity that allows them to relieve the body's immune response by inhibiting inflammation and immune response of T cells
Lee and his team tried to analyze the therapeutic effects of these cells in the treatment of lupus nephritis. They used a mouse model for transplantation of cord blood cells, having proved effective in other immune system diseases.
Thus, as explained, "have shown that transplantation causes a marked delay the deterioration of renal function, reduces levels of certain antibodies, relieves the changes in renal disease and the development of proteinuria, a sign of kidney damage. "
also observed a positive difference in survival rates of mice were treated with two months of life compared with those rodents than six months old, which has led researchers to believe that early transplant may be more effective.
The researchers also opt for the option of an allogeneic transplant and non-autologous (patient's own cells), under the therapeutic effects observed in this study.
"The ability of these cells to reduce inflammation shows that it is likely to be useful for treating autoimmune diseases and this study supports this argument," said David Eve, associate editor of 'Cell in Transplantation. "
Source: europapress.es
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