The University of Michigan established the first line in that state of stem cells from embryos carrying genes responsible for inherited diseases, which will study the onset and progress of genetic disorders and the search for new treatments.
This University of Michigan (UM) joined the small group of U.S. universities with this specific lines for certain diseases, which has called UM9-1 and UM11-1, developed by researchers at the Consortium for Therapies Stem Cells institution.
UM9-1 line carries the genetic defect that causes hemophilia B, a hereditary condition in which blood does not clot properly.
While UM11-1 is carrying the disease gene responsible for Charcot-Marie-Tooth disease, an inherited neurological disorder characterized by degeneration progressive muscle of the foot, lower leg and hand.
Both are the only lines in the Federal Register carriers of these three genes for specific diseases that exist in the same register, which contains 91 lines of human embryonic stem cells, the university said.
To obtain the UM is based on Michigan law states that if human embryos created for reproduction but were found not suitable for such use because they carry disease, are donated for research Instead of being destroyed.
In the months and years following the embryos donated will be used, for example, to create cell lines that carry the genes responsible for myotonic dystrophy, Huntington's disease, Rett syndrome, spinal muscular atrophy and Tay-Sachs evil .
The consortium will distribute samples UM9-1 and UM11-1 to researchers around the campus and statewide partners and the National Institutes of Health United States for inclusion on the National Register lines of human embryonic stem cells eligible for federal funding of research.
These are the second and third lines of human embryonic stem cells developed by the consortium, after UM4-6 was announced in October and was derived from an embryo of five days, normal genetically created for reproductive purposes but no longer be necessary for this was donated to UM.
The creation of the three lines was possible because Michigan voters in November 2008 approved Proposition 2, a state constitutional amendment which allowed scientists to derive stem cell lines using embryos left over from the clinics fertility.
The amendment also allowed collaboration between UM and the Genesis Genetics Company, based in Detroit, the leading global provider of genetic diagnostic testing prior to implantation.
These tests are tests to identify embryos a few days, carriers of genetic mutations that are responsible for hereditary diseases.
Genesis Genetics held every year nearly four thousand examinations and following the agreement with the university patients with embryos that are positive for a genetic disease have the option of donating those embryos to UM Consortium.
Source: informador.com.mx
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