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The cord blood bank opens its inception with a donation

Delivery service Elche General Hospital launched yesterday, so and as planned, the bank collection of umbilical cord blood thanks to the donation of a woman giving birth before the relevant authorization made so they could extract samples. With this donation has been given the go-ahead to a service that already had been providing in several hospitals in the province and the members of the team had no intention of joining Obstetrics long.

The process begins with the informed consent of the mother after what the professionals come to the collection of umbilical cord blood at delivery in a process that takes no more than a few minutes. After removing the blood, it is stored in a refrigerator and in completing the necessary documents to accompany the bags to the Transfusion Centre of Alicante, being professionals in this center managers refer to the Bank Umbilical Cord Blood Center Transfusion of Valencia. At present, the staff is emphasizing that the information reaches all pregnant women to participate in the project if they so wish.

The umbilical cord blood is used, especially for stem cell transplantation bone marrow appears to give better results than adult implant.

Source: diarioinformacion.com

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stem cells into neurons

Researchers at the University of California in the United States have created c Elul mother can become various types of neurons avoiding the risk of forming tumors, according to a study published in the online edition of the journal Proceedings of the National Academy of Sciences' (PNAS).

Scientists have distinct neural these c Elul from embryonic stem cells . These cells, which have the potential to become in any body tissue, have seen limited use, mostly because of its potential to generate tumors.

addition to avoid this risk, the procedure used by researchers has created the cells in large quantities and are stable cell cultures is essential for its usefulness in the drug field.

explains Kang Zhang, head of the study and director of the Institute of Genomic Medicine, University of California, "we can quickly generate stable stem cells in large quantities (millions in less than a week), so that can be used clinical trials and, ultimately, treatments, something that until now was not possible. "

to generate neural stem cells, Zhang and colleagues added a series of small molecules with a chemical solution that induces cells embryonic stem cells to become neural precursors, but paralyzed the process before differentiation occurs. "As we do not use gene transfer technologies or exogenous cellular products, the risk of mutations or contamination is minimal," added Zhang.

This procedure allows researchers are able to make cells precursor showed no evidence of tumor formation when they are introduced into laboratory mice.

By adding other chemicals, scientists have been able to direct the differentiation of precursor cells into different types of mature neurons. Zhang notes that as meaning that we can explore possible clinical applications for a wide range of neurodegenerative diseases.

"You can generate neurons for specific disorders such as amyotrophic lateral sclerosis (ALS), Parkinson's disease or, in the case of my area of \u200b\u200bresearch, specific neurons eyes lost in macular degeneration, retinitis pigmentosa or glaucoma, "said Zhang, a professor of ophthalmology and human genetics at the Shiley Eye Center.

The new process suggests the possibility of wide applications in cell research mother. The same method can be used to induce pluripotent stem cells (stem cells derived from mature cells artificially differentiated adult) to become neural stem cells.

"And in principle, by altering the combination of small molecules could be created other types of stem cells able to become heart cells, pancreas and muscle, to name a few, "says the researcher.

Zhang concludes that the next step is to use stem cells to treat various types in animal models of neurodegenerative diseases such as macular degeneration or glaucoma.

Source: europapress.es

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Stem Cells for infertility

Stem Cells for infertility

Valencia .- The director of the Center for Education and Research with embryonic stem cells University Stanford, Renee Reijo, said that knowing the passage of cell gamete mother will prevent infertility.

Reijo, a leading researcher in the creation of artificial gametes from pluripotent stem cells has made these statements in the fourth International Congress of IVI, which until last Saturday met in Valencia to a thousand experts in assisted reproduction, according to a statement from the organization.

lines stem cells grown in the lab provide scientists the opportunity to use in treating diseases like diabetes, obesity, Parkinson and infertility.

Renee Reijo

According to the development of diseases like cancer or Parkinson 'occurs at some point in the stem cells become specialized cells "and the current challenge is to understand this process identify the key moment and to act to prevent further development. "

"We've already covered half the way in creating artificial eggs and sperm, but we need further research to achieve better quality gametes," said Reijo, who added that this would allow "the creation of gametes Patients who do not have them, that could avoid the donation. "

The Center for Education and Research with embryonic stem cells at Stanford University is also investigating another potential application of stem cells: making cells and tissues for medical treatment, so that People who need a transplant to resort to its own cells and, thus, prevent transplant rejection posed.

Moreover, the president of IVI, Antonio Pellicer, has said that in assisted reproduction "challenge is making life more comfortable for the patient through the humanization Maximum treatments. "

According Pellicer, mimic the natural conception process passes to avoid multiple pregnancies and ovarian hyperstimulation, which has virtually disappeared with the new drugs.

" The major cause of abandonment in assisted reproduction treatments is stress, mainly due to the medication, and is now moving from daily injections to oral drugs, which standardizes the process of looking for a baby to the patient, "says Pelletier.

Finally, Pellicer has stressed the importance that had in recent years the clinical application of vitrification prevents the woman to have more of a process of ovarian stimulation.

Source: EFE

Stem Cells for infertility

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umbilical cord stem cells to treat lupus

umbilical cord stem cells to treat lupus

Researchers at National Yang- Ming University, Taiwan, China, ensure that mesenchymal stem cells derived from umbilical cord blood may represent a new therapeutic alternative for the treatment of nephritis Lupus, a major complication of systemic lupus erythematosus.

This follows from the results of a study in mice whose results are published in its latest issue, the journal Cell in Transplantation. "

explains the study's lead author, Dr. Oscar K. Lee, these cells have been shown to possess immune-modulating capacity that allows them to relieve the body's immune response by inhibiting inflammation and immune response of T cells

Lee and his team tried to analyze the therapeutic effects of these cells in the treatment of lupus nephritis. They used a mouse model for transplantation of cord blood cells, having proved effective in other immune system diseases.

Thus, as explained, "have shown that transplantation causes a marked delay the deterioration of renal function, reduces levels of certain antibodies, relieves the changes in renal disease and the development of proteinuria, a sign of kidney damage. "

also observed a positive difference in survival rates of mice were treated with two months of life compared with those rodents than six months old, which has led researchers to believe that early transplant may be more effective.

The researchers also opt for the option of an allogeneic transplant and non-autologous (patient's own cells), under the therapeutic effects observed in this study.

"The ability of these cells to reduce inflammation shows that it is likely to be useful for treating autoimmune diseases and this study supports this argument," said David Eve, associate editor of 'Cell in Transplantation. "

Source: europapress.es

umbilical cord stem cells to treat lupus

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Stem cells are to cure many diseases

The stem cells will cure many diseases

The head of the Hematology Service of the Hospital de Palencia, Fernando Ortega, has given a lecture organized by the School of Pastoral Care, entitled "Controversies in the therapeutic use of stem cells."

- What are these disputes?

"The stem cell issue is very controversial for its own origin. There are two types of stem cells. Some are embryonic and other stem cells adult. These do not pose ethical problems because they are cells taken from adult human. However, the embryo are those obtained from studies done of fertilization in vitro, surplus to assisted reproduction. These embryos are used to obtain stem cells, and in consequence they are destroyed. Embryonic stem cells have great potential differentiator to transform into other tissues are unstable and easily develop tumors which are implanted. There are no clinical trials to investigate its use in humans, only animals. They have won the battle of adult stem cells, which have a similar behavior to embryonic, but are safer and do not develop cancers and tumors.

- A Catholic can accept the use of this type of progress with stem cells?

"I understand that a Catholic can not accept the fact of destroying an embryo because the embryo is a living being and a human. With stem cell research on embryos are destroyed thousands, which for a Christian is unacceptable.

- What are the drawbacks stem cells.

"The research is very slow, because the manipulation of cells is always complex, many problems arise, as to be maintained in culture cells and then begin testing in animals (mice, pigs, rabbits ...) to finally decide to use in humans. Stem cells are going to lead a revolution and will cure many diseases. However, take time to stem cell therapy is useful.

- Are you in favor of therapeutic use?

-Partisan with adult stem cells, not embryonic stem cells, which are forbidden even by most governments.

- How far will science?

-Science always opens the right track. Genetic manipulation and cloning of human beings, which is reprehensible, I am convinced that science is going to stop. Science seeks the ultimate way to solve the problems that human beings really are, which include health.

Source: The

nortecastilla.es stem cells will cure many diseases

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know the passage of a stem cell to prevent infertility

know the passage of a stem cell gamete to prevent infertility

Director of Centre for Education and Research with embryonic stem cells at Stanford University, Renee Reijo, said that knowing the step of gamete mother cell to help to avoid infertility.

Reijo, a leading researcher in the creation of artificial gametes from pluripotent stem cells has made these statements in the fourth International Congress of IVI, which until last Saturday met in Valencia to a thousand experts playing assisted, according to a statement from the organization.

stem cell lines grown in the lab provide scientists the opportunity to use in treating diseases like diabetes, obesity, Parkinson and infertility. According to Renée

Reijo, the development of diseases like cancer or Parkinson 'occurs in a time when stem cells become specialized cells "and the current challenge is to understand the process to detect the key moment and to act to prevent further development. "

"We've already covered half the way in creating artificial eggs and sperm, but we need further research to achieve better quality gametes," said Reijo, who added that this would allow "the creation of gametes in patients not have them, which could prevent the donation. "

The Center for Education and Research on cells embryonic stem Stanford University is also investigating another potential application of stem cells: making cells and tissues for medical treatment, so that people who need a transplant to resort to its own cells and, thus, avoid rejection involving transplants.

Moreover, the president of IVI, Antonio Pellicer, has said that in assisted reproduction "the challenge is to make life more comfortable for the patient through the full humanization of the treatment." According

Pellicer, mimic the natural conception process passes to avoid multiple pregnancies and ovarian hyperstimulation has virtually disappeared with the new drugs.

"The major cause of neglect in assisted reproduction treatments is stress, mainly due to the medication, and is now moving from daily injections to oral drugs, which standardizes the process of looking for a baby to patient, "says Pelletier.

Finally, Pellicer has stressed the importance it has had in recent years the clinical application of vitrification prevents the woman to have more of a process of ovarian stimulation. Source: EFE

know the passage of a stem cell Gamete to prevent infertility

Scientists achieve

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gamete Scientists fail to generate neurons from stem cells

generate neurons from stem cells

A group of U.S. scientists has succeeded for the first time, generating neurons from stem cells with induced pluripotent (iPSC) in patients with schizophrenia. The results of this work, published this week in Nature, show that neurons generated from iPSC cells of schizophrenic patients are able to generate fewer neural connections than the rest.

This research, led by Fred Gage, Professor, Laboratory of Genetics at the Salk Institute in California, U.S., has discovered that an antipsychotic drug commonly used to treat this disease, loxapine, is able to restore the connectivity between these new cells and also affected the activity of hundreds gene.

To make this work, scientists reprogrammed skin fibroblasts from four schizophrenic patients with a hereditary predisposition to the disease. The authors differentiate these reprogrammed cells (iPSC) in neurons.

then used a modified rabies virus to highlight the connections between neurons, allowing to detect the differences between neurons from normal and schizophrenic patients.

With the viral tracer observed that the neurons of patients were connected to each other less often and had fewer projections grow out from their cell bodies. For its part, the gene expression profiles identified almost 600 genes whose activity was poorly regulated in these neurons.

A NEW MODEL FOR DRUG DESIGN

During the last three weeks of cell differentiation, the researchers administered a series of drugs commonly prescribed antipsychotics. Loxapine was the only one who acted on dopamine receptors in the brain, increasing the ability of neurons to reach out to their neighbors' and to connect. This drug also affected the activity of hundreds of genes.

Experts expect that this new model is useful for designing new drugs against this disease, which affects 1 percent of world population.

As explained Gage SINC statements gathered by Europa Press, describing the biological mechanisms underlying this disease is "a major step in the research field because for many years been considered a disease only 'social' "." It is true that the environment affects schizophrenia, but there are a lot of components that are genetically determined, "he says.

However, it remains without knowing the root cause that generates schizophrenia. "Without a minimal understanding of the causes and pathophysiology of this mental disorder, we lack the tools necessary to develop effective treatments or preventive measures," he says.

Source : Scientists

europapress.es fail to generate neurons from stem cells

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Stem Cells, a promise against diabetes

Stem Cells, a promise against diabetes

The stem cells help treat diabetes in "ten or fifteen years", as the director said Friday Department of Stem Cell Development in Miami, Juan Domínguez-Bendala, who participated in the XXII National Congress on the disease to be held in Malaga, a meeting also attended by the researcher and former health minister, Bernat Soria.

Domínguez-Bendala

explained that "although our intention is to expand rapidly" treatment with stem cells, "we can never give an exact date until we have the safety and efficacy sufficient." "The use of stem cells is very important because they are immortal cells and readily available but must be stressed that provide insulin cells that are not as easy to generate other," he explained.

The former minister has referred to the different cell therapy clinical trials being carried out in Andalusia, "who has been a pioneer in this field." For the moment, has conducted a trial with patient's own stem cells to avoid what is known as diabetic foot, which results amputation of the same. According to Soria, the results of this test, performed on 20 patients of Andalusia, has been positive and "not only prevented the amputation but they have improved the health of the sick."

However, this treatment is included as one of the benefits offered by the health system, Soria explained that "still have to study in hospitals across the country and follow up to last two to three years in all patients to have all the assurances that offer a safe and effective treatment. "

Finally, he noted that currently being undertaken, in several hospitals present another set of trials with various types of cells, "we will post results when they are completed."

According to recent studies by the World Health Organization (WHO), there may be more than 220 million people with diabetes worldwide and within 15 or 20 years this number may exceed five hundred million people affected. Furthermore, in Spain, more than 13.5% of adults have diabetes and many others at risk of developing diabetes by high glucose levels recorded due to the increase in unhealthy lifestyles, commented Friday el ex ministro de Sanidad, Bernat Soria.

Estos datos, extraídos del primer estudio estatal sobre esta enfermedad, ponen de maniesto que "la salud pública debe tener en cuenta tanto a la diabetes como a los problemas que ésta conlleva", ha indicado Soria asegurando que "si queremos aumentar la salud de los españoles tenemos que investigar y estar comprometidos con todos los campos".

Fuente: elmundo.es

Células madre , una promesa contra la diabetes

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The boy Joel improvement after stem cell transplantation

La concejala de Solidaridad, Remedios Herrero, ha recibido al niño y al padre para felicitarlos by resultados.La family thanked the people of Benalmádena has provided collaboration in actions aimed at raising funds.

Councillor Solidarity, Remedios Herrero, received this morning, Joel Ortega, the child Benalmadena which have managed to raise enough funds so it can be operated in an intervention that has been made in Germany reduce the incidence of cerebral palsy being treated. Marcelo Ortega, Joel's father, explained that since the intervention, taken last February, the child has experienced some improvement, as it has reduced pain and increased expression.

Marcelo Ortega thanked the people of Benalmádena deep collaboration that has paid in actions aimed at raising funds and to City Council and the Councillor of Solidarity, "who have spread these actions so that the neighbors involved," . In addition, explained that the improvements will be produced as the months have elapsed since such recoveries are slow.

Meanwhile, Remedios Smith has congratulated the family of Joel and achievements, and he has delivered some gifts to the child. "I am pleased today to see Joel after having been operated successfully, thanks to support and affection of all who have contributed to this improvement a reality, "said the mayor.

Benalmadena

Little, 13, has been undergoing a transplant of stem cells that will reduce cerebral palsy by 70 percent and give him the chance to speak, pick up objects with hands and, at best, to walk. The intervention and the cost of it has come at a cost of 9,000 euros.

Source: benalmadenanoticias.es

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retina Crean mouse stem cell

Japanese scientists announced the creation of a retina in the laboratory from embryonic cells, which is an important step for the treatment of diseases of this tissue, even some forms of blindness.

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public banks in Spain

public umbilical cord banks in Spain

Storing cord blood takes place in public banks umbilical cord, of which there are seven approved in Spain , specifically: Barcelona

• Galicia
• Madrid Malaga Tenerife
• Asturias Valencia

Subsequently, the blood is used for stem cell adult obtained from umbilical cord fluid, a more effective alternative to traditional bone marrow transplantation, decreasing the likelihood that there is a rejection and improves and accelerates the clinical outcome.

The umbilical cord blood has not only hematopoietic stem cells (capable of forming several types of blood cells), but also has mesenchymal stem cells, which may allow the creation of cells neural, bone cells, heart muscle and other muscle cells.

umbilical cord blood has the ability to regenerate the bone marrow and immune system when it is depressed, either by a disease of the bone marrow, or by a previous chemotherapy treatment (used as conditioning prior to the preparation of the patient to be transplanted with hematopoietic stem cells).

The results of numerous clinical trials in recent years indicate that there is less chance of having a transplant rejection if used by umbilical cord blood.

According to scientists, the most likely reason for this is that immune system cells of the newborn are less developed than adults. Have set up banks that store cord for use in transplants for people compatible.

Source: diarioinformacion.com

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umbilical cord blood bank umbilical cord in Elche

The General Hospital of Elche has already prepared the necessary procedures to implement the bank collecting umbilical cord blood , a practice that with the approval of the general direction of management, Health Assessment and Research of the Department of Health since last September, but a few days ago that the center has the necessary refrigeration equipment to conserve the liquid.

Therefore, the center plans to start Elche withdrawals from next Monday between the mothers who so wish. "Pregnant women are informed of this possibility by midwives in the health center, which will give all the information and are seek informed consent. Here is where women decide what they can collect the cord blood and cases where it is contraindicated, for example, among women who suffer from some diseases, including those that have given birth less than 34 weeks of gestation or in multiple pregnancies, "said Alfredo Millá, section chief in the area of \u200b\u200bObstetrics General Hospital Elche.

Therefore, service members of Gynecology and Obstetrics and Haematology, key stakeholders in carrying out this process, last week attended a training lecture given by Dr. Pilar Solbes, member of the Center Transfusion of Valencia and the seat of Cord Blood Bank , which will target the extractions carried out in Elche. Solbes told the audience the various protocols for action and documentation required to perform the extractions.

The extraction of the blood does not take more than a few minutes and once obtained it will be stored in a refrigerator and completed documents required to accompany the bags to the Transfusion Centre of Alicante, with professionals of this organism in charge of forwarding them to Bank Umbilical Cord Blood Transfusion Center Valencia.

Team members are expected Elche daily blood collection and forwarding it to the end of each day Transfusion Center for storage and use anywhere in the country. "It's important that mothers are aware that this type of donation not mean having the cord itself for future children, but will be autonomous transplant coordinators who identify potential recipients of blood in our country or abroad. The umbilical cord blood will be used for clinical or therapeutic use and research, "said Miller, who stressed that the process of cord blood collection is not only available of pregnant women assigned to General Hospital but to all women who want to make the donation and that, therefore, may give birth in the middle of the street gardens and Mills.

The refrigeration unit is already physically in the hospital delivery area of \u200b\u200bElche, where he recorded a daily average of four or five deliveries. The importance of collecting cord blood is that it contains stem cells that are vital for the renewal of blood cells in patients who have impaired bone marrow.

Once in the Community and four in the province

The Valencian Community has at present eleven hospitals that are approved for the extraction of umbilical cord blood, and of these, four are in the province of Alicante. Specifically, the centers licensed to perform these extractions are La Fe, La Ribera, La Plana, The Clinic, Doctor Peset, Lluis Alcanyis, General de Castellón, General de Alicante, San Juan de Alicante, Hospital de la Vega Baja (Orihuela) and Hospital de Torrevieja. They will be joined on Monday the General Hospital of Elche which takes months to manage the relevant authorization from the Department of Health, as unwieldy accreditation requires permits to confirm the ability of the clinic in question to perform the extractions. The last step was the purchase of refrigeration equipment in the hospital Elche store the blood until the time comes to be forwarded to the Transfusion Centre of Valencia.

Source: diarioinformacion.com

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Establish stem cell line to study genetic disorders Crean first heart

The University of Michigan established the first line in that state of stem cells from embryos carrying genes responsible for inherited diseases, which will study the onset and progress of genetic disorders and the search for new treatments.

This University of Michigan (UM) joined the small group of U.S. universities with this specific lines for certain diseases, which has called UM9-1 and UM11-1, developed by researchers at the Consortium for Therapies Stem Cells institution.

UM9-1 line carries the genetic defect that causes hemophilia B, a hereditary condition in which blood does not clot properly.

While UM11-1 is carrying the disease gene responsible for Charcot-Marie-Tooth disease, an inherited neurological disorder characterized by degeneration progressive muscle of the foot, lower leg and hand.

Both are the only lines in the Federal Register carriers of these three genes for specific diseases that exist in the same register, which contains 91 lines of human embryonic stem cells, the university said.

To obtain the UM is based on Michigan law states that if human embryos created for reproduction but were found not suitable for such use because they carry disease, are donated for research Instead of being destroyed.

In the months and years following the embryos donated will be used, for example, to create cell lines that carry the genes responsible for myotonic dystrophy, Huntington's disease, Rett syndrome, spinal muscular atrophy and Tay-Sachs evil .

The consortium will distribute samples UM9-1 and UM11-1 to researchers around the campus and statewide partners and the National Institutes of Health United States for inclusion on the National Register lines of human embryonic stem cells eligible for federal funding of research.

These are the second and third lines of human embryonic stem cells developed by the consortium, after UM4-6 was announced in October and was derived from an embryo of five days, normal genetically created for reproductive purposes but no longer be necessary for this was donated to UM.

The creation of the three lines was possible because Michigan voters in November 2008 approved Proposition 2, a state constitutional amendment which allowed scientists to derive stem cell lines using embryos left over from the clinics fertility.

The amendment also allowed collaboration between UM and the Genesis Genetics Company, based in Detroit, the leading global provider of genetic diagnostic testing prior to implantation.

These tests are tests to identify embryos a few days, carriers of genetic mutations that are responsible for hereditary diseases.

Genesis Genetics held every year nearly four thousand examinations and following the agreement with the university patients with embryos that are positive for a genetic disease have the option of donating those embryos to UM Consortium.

Source: informador.com.mx

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laboratory

used a donor heart, which used only its external structure. Then it was repopulated with stem cells receptor potential.