Hospital Universitario Central de Asturias (HUCA) has managed to heal pressure ulcers and 19 of the 22 paraplegic patients included in clinical trials with stem cells bone marrow. The research just published in the journal "The Journal of Spinal Cord Medicine." According to the authors, this is the first stem cell treatment designed in Spain and one of the first in the world, which is effective for typical fistulas (or "sores") often experienced by people confined to bed and reduced mobility and can easily get to be a difficult problem.
The test was carried out by the coordination unit transplantation and cell therapy HUCA. The first signatories of the article are Sarasu Julian Gonzalez, chief of plastic surgery department, who is retiring the same day, "and Silvia López Pérez, biologist of that unit. The other signatories of the article are Jesus Otero, director of the transplant unit and cell therapy, "Dolores Escudero, Coordinator HUCA transplants, biologists María Álvarez Viejo, Marcos Perez and Yolanda Menéndez, hematologists Angeles Gala Fernandez and Jose Garcia, Amaia Ferrero biochemistry, and the plastic surgeon Ángel Pérez Arias.
"It is estimated that at least 85 percent of paraplegic patients developed pressure ulcers at some point in their lives", explained yesterday to THE NEW SPAIN Silvia Perez, who added that injuries of this type are difficult treated with conventional therapy, so that "often become a chronic and highly recurrent."
The team of Central Hospital of Asturias began its work by similar investigations of other groups that had reaped positive results with bone marrow stem cells applied to chronic wounds. None of them had been held in Spain. The trial, funded by the FICYT-focused on paraplegic patients. Specifically, in 22 patients (19 men and 3 women) with a mean age of 56 years presenting with severe pressure ulcers and more than four months. They shared that they had not responded to topical treatment. Thirteen of them had previously undergone surgery without positive results.
Silvia
Perez explains how processes were developed. Eligible patients were subjected to a puncture of the iliac crest to obtain mononuclear cells by density gradient. After three hours of collection, and once processed and purified cell fraction desired, this product was inoculated to the patients in the operating room, where shortly before the arrival of the cells had undergone minimal surgical intervention consisting of a cleaning and debridement of the wound with saline. Then the wound margins were united by suture, creating a space in which the suspension was inoculated Cell.
HUCA multidisciplinary team concluded that cell therapy designed for the test is a very valid option for the treatment of pressure ulcers in type IV, the most serious, those in which there is necrosis of muscle , bones, joints and surrounding tissues.
Hospital Universitario Central de Asturias (HUCA) launched a few years ago three clinical trials based on the use of stem cells. One of them was the use of pancreatic islets for diabetes sufferers. Started yielding good results, but the bottom line was not satisfactory. The other focuses on the application of stem cells to infarcted hearts, the results have not been published yet.
Source: lne.es
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